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KMID : 0363320060270010166
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 1 p.166 ~ p.177
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Effect of Orostschys japonicus A. Berger on Apoptosis in K562 Cell Lines
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Yun Kyoung-Su
Woo Hong-Jung
Kim Young-Chul
Lee Jang-Hoon
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Abstract
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Objectives : This study was performed to determine if Orostschys japonicus A. Berger has protective effects against CML in K562 cell lines.
Materials and Methods : MTT assay, cell proliferation assay, Reverse transcription-polymerase reaction chain, RT-PCR, DNA fragmentation assay, Quantitative PCR were studied.
Results : Orostschys japonicus A. Berger had no effects on Bax gene in K562 cell lines, but decreased Bcl-2 gene, and increased the Caspases-3 gene. This is indicate of induced apoptosis in K562 cell lines by Orostschys japonicus A. Berger.
Conclusion : These results suggest that Orostschys japonicus A. Berger has effects on apatosis in K562 cell lines.
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KEYWORD
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Orostschys japonicus A. Berger, K562 cell lines, apoptosis, Bax, Bcl-2, Caspase
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